Treatment
This study consists of two different treatment options:
- Avutometinib + Defactinib
- Standard therapy (Caelyx, Paclitaxel, Topotecan, Anastrazole or Letrozole)
Avutometinib is administered as a tablet twice per week.
Defactinib is administred as a tablet twice daily.
Caelyx is administered intravenously every 4 weeks.
Paclitaxel and Topotecan are administered intravenously on three subsequent weeks, followed by a week off.
Anastrazole and Letrozole are administered daily as a tablet.
You will be randomly allocated to one of the treatment groups. In case you are randomized to the group receiving standard therapy your treating physician will decide which of the drugs is best suited for you.
Treatment duration
The treatments can continue until disease progression, unacceptable toxicities or until you decide to stop.
Contact
To be able to give you the best information and care we do not give medical advice via mail. We kindly ask you to make an appointment via lgog@uzleuven.be.